The mechanism of action of IgG in primary immunodeficiency (PI) disease has not been fully elucidated. It is known that Privigen provides patients with a broad spectrum of opsonic and neutralizing IgG antibodies against bacterial, viral, parasitic, and mycoplasma agents and their toxins.

  • Privigen is manufactured from the plasma of a large pool of healthy blood donors and therefore includes a broad variety of antibody specificities against common pathogens to which the donor population has been exposed19
  • The antibodies in Privigen are structurally and functionally intact, and their effector functions are fully operative15
Privigen is stabilized with proline

The mechanism of action of IgG in chronic immune thrombocytopenic purpura (ITP) is complex and not fully understood. However, the success of treating chronic ITP with IgG has been attributed to the competitive inhibition of Fc receptors on phagocytic cells.20, 21

Continuing research indicates that other mechanisms may also contribute to inhibiting thrombocytopenia. Other mechanisms that may also play a role include19:

  • Induction of Fcγ IIb inhibitory receptors, which appear to play a critical role in thrombocytopenia
  • Regulatory properties of anti-idiotypic antibodies, which possibly regulate the immune system
  • The long-term effects of IVIg on the immune system

Although IVIg has been used to treat chronic ITP, the mechanism of action is still unclear. Further research will be needed to better understand how IVIg works in chronic ITP.19

IgG MOA in chronic ITP is complex
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