Billing & Diagnosis Codes | PRIVIGEN Immune Globulin Intravenous (Human), 10% Liquid

This resource provides information from a complex and evolving medical coding system. The treating physician is solely responsible for diagnosis coding and determination of the appropriate ICD-10-CM codes^1,2 that describe the patient’s condition and are supported by the medical record. All codes listed in this guide are for informational purposes and are not an exhaustive list. The CPT^®,³ HCPCS,^4,5 and ICD-10-CM codes provided are based on AMA or CMS guidelines. The billing party is solely responsible for coding of services (eg, CPT coding). Because government and other third-party payer coding requirements change periodically, please verify current coding requirements directly with the payer being billed.

Medicare, Medicaid, and most insurers cover Privigen for the treatment of patients with primary immunodeficiency (PI), immune thrombocytopenic purpura (ITP), and chronic inflammatory demyelinating polyneuropathy (CIDP). Medicaid coverage varies by state, and coverage by other payers varies by plan and by contract.

Medicare coverage and billing requirements are dependent in part on where the patient is treated. Privigen is covered by Medicare Part B for treatment in the patient’s home only for diagnoses with an asterisk. All other diagnoses are eligible for coverage in the home under Medicare Part D.

Download the Prescription Referral Form to confirm insurance coverage options.

The following ICD-10-CM codes may be used to identify patient immunologic medical conditions typically associated with Privigen use.

D69

Purpura and other hemorrhagic conditions

D69.3

Immune thrombocytopenic purpura Hemorrhagic (thrombocytopenic) purpura Idiopathic thrombocytopenic purpura Tidal platelet dysgenesis

D80

Immunodeficiency with predominantly antibody defects

D80.0*

Hereditary hypogammaglobulinemia Autosomal recessive agammaglobulinemia (Swiss type) X-linked agammaglobulinemia [Bruton] (with growth hormone deficiency)

D80.1

Nonfamilial hypogammaglobulinemia Agammaglobulinemia with immunoglobulin-bearing B-lymphocytes Common variable agammaglobulinemia [CVAgamma] Hypogammaglobulinemia NOS

D80.2*

Selective deficiency of immunoglobulin A [IgA]

D80.3*

Selective deficiency of immunoglobulin G [IgG] subclasses

D80.4*

Selective deficiency of immunoglobulin M [IgM]

D80.5*

Immunodeficiency with increased immunoglobulin M [IgM]

D80.6*

Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia

D80.7*

Transient hypogammaglobulinemia of infancy

D80.8

Other immunodeficiencies with predominantly antibody defects Kappa light chain deficiency

D80.9

Immunodeficiency with predominantly antibody defects, unspecified

D81

Combined immunodeficiencies

Excludes:

autosomal recessive agammaglobulinemia (Swiss type) (D80.0)

D81.0*

Severe combined immunodeficiency [SCID] with reticular dysgenesis

D81.1*

Severe combined immunodeficiency [SCID] with low T- and B-cell numbers

D81.2*

Severe combined immunodeficiency [SCID] with low or normal B-cell numbers

D81.31

Severe combined immunodeficiency [SCID] due to adenosine deaminase deficiency ADA deficiency with SCID Adenosine deaminase [ADA] deficiency with severe combined immunodeficiency

D81.5*

Purine nucleoside phosphorylase [PNP] deficiency

D81.6*

Major histocompatibility complex class I deficiency Bare lymphocyte syndrome

D81.7*

Major histocompatibility complex class II deficiency

D81.82*

Activated Phosphoinositide 3-kinase Delta Syndrome [APDS] p110d-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency[PASLI] disease

D81.89*

Other combined immunodeficiencies

D81.9*

Combined immunodeficiency, unspecified Severe combined immunodeficiency disorder [SCID] NOS

D82

Immunodeficiency associated with other major defects

Excludes:

ataxia telangiectasia [Louis-Bar] (G11.3)

D82.0*

Wiskott-Aldrich syndrome Immunodeficiency with thrombocytopenia and eczema

D82.2

Immunodeficiency with short-limbed stature

D82.3

Immunodeficiency following hereditary defective response to Epstein-Barr virus X-linked lymphoproliferative disease

D82.4*

Hyperimmunoglobulin E [IgE] syndrome

D82.8

Immunodeficiency associated with other specified major defects

D82.9

Immunodeficiency associated with major defect, unspecified

D83

Common variable immunodeficiency

D83.0*

Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function

D83.1*

Common variable immunodeficiency with predominant immunoregulatory T-cell disorders

D83.2*

Common variable immunodeficiency with autoantibodies to B- or T-cells

D83.8*

Other common variable immunodeficiencies

D83.9*

Common variable immunodeficiency, unspecified

G11

Hereditary Ataxia

G11.3*

Cerebellar ataxia with defective DNA repair Ataxia telangiectasia [Louis-Bar]

G61

Inflammatory polyneuropathy

G61.81

Chronic inflammatory demyelinating polyneuritis

CPT^® and HCPCS Codes (Healthcare Common Procedural Coding System)^2-5

S9338^†

Home infusion therapy, immunotherapy, administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment (drugs and nursing visits coded separately), per diem

J1459

Injection, immune globulin (Privigen), intravenous, non-lyophilized (eg, liquid), 500 mg

Q2052

Services, supplies, and accessories used in the home for the administration of IVIg

96365

Intravenous infusion, for therapy and prophylaxis or diagnosis (specify substance or drug); initial, up to 1 hour

96366

Each additional hour (list separately in addition to code for primary procedure)

*Medicare Part B-approved diagnosis codes for treatment with Privigen in the home and in the clinic. All other diagnosis codes may qualify for coverage under Medicare Part B in the clinic or Medicare Part D plans in the home. Medicare Part D plans do not cover ancillary infusion supplies or nursing.

†S-codes are HCPCS codes used by some private health plans for billing and reimbursement. Medicaid plans may use S-codes as well, but Medicare does not use them.

CPT, Current Procedural Terminology; HCPCS, Healthcare Common Procedure Coding System; ICD-10-CM, International Classification of Diseases, 10th Revision, Clinical Modification.

Keep the diagnosis and billing codes handy

View and download the Privigen Coding Guide

Get the Coding Guide

References: 1. Centers for Disease Control and Prevention (CDC). National Center for Health Statistics (NCHS). ICD-10-CM Files. https://www.cdc.gov/nchs/icd/icd-10-cm/files.html?CDC_AAref_Val=https://www.cdc.gov/nchs/icd/comprehensive-listing-of-icd-10-cm-files.htm. Accessed April 30, 2026. 2. National Center for Health Statistics – ICD-10-CM. https://icd10cmtool.cdc.gov/?fy=FY2026. Accessed April 30, 2026. 3. American Association of Professional Coders (AAPC). Codify. CPT Codes. https://www.aapc.com/codes/cpt-codes/. Accessed April 30, 2026. 4. American Association of Professional Coders (AAPC). Codify. https://www.aapc.com/codes/hcpcs-codes. Accessed April 30, 2026. 5. Centers for Medicare and Medicaid Services (CMS). HCPCS Quarterly Update. https://www.cms.gov/medicare/coding-billing/healthcare-common-procedure-system/quarterly-update. Accessed April 30, 2026.

Billing and diagnosis codes