Features of proline stabilization include17:

  • Reduced IgG aggregation
  • Reduced dimer formation
  • Minimized fragmentation
  • Prevention of solution discoloration
  • Room-temperature storage

How proline works

Proline interacts with hydrophobic groups in the IgG molecule, thereby reducing protein-protein association and dimerization; in other words, it stabilizes IgG molecules as monomers.17 The images below show dimer formation in IgG solutions with proline and without proline.

Dimer formation without proline

Dimerization can occur without proline

In solution, IgG molecules (shown in blue) reversibly bind to each other (circled), forming IgG dimers.17

Proline reduces dimer formation

Proline inhibits dimer formation and stabilizes IgG molecules

Proline (shown in yellow) may shield the IgG molecules from one another and thus interfere with dimer formation.17

Pharmacokinetic data indicate that proline*18:

  • Is rapidly cleared from circulation
  • Does not accumulate after treatment

IVIg therapies designed with proline may be considered for patients with diabetes and certain allergies and intolerances.19

  • Privigen is contraindicated in patients with hyperprolinemia.
*Clinical significance is unknown.

Designed for stability, Privigen is also safe and effective

See how Privigen did in clinical studies

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