Proline interacts with hydrophobic groups in the IgG molecule, thereby reducing protein-protein association and dimerization; in other words, it stabilizes IgG molecules as monomers.19 The images below show dimer formation in IgG solutions with proline and without proline.
In solution, IgG molecules (shown in blue) reversibly bind to each other (circled).19
Proline may shield IgG molecules from binding together.19
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