Features of proline stabilization include19:

  • Reduced IgG aggregation
  • Reduced dimer formation
  • Minimized fragmentation
  • Prevention of solution discoloration
  • Room-temperature storage*
*Up to 36-month room-temperature storage, as indicated by the expiration date printed on the outer carton and vial label.

How proline works

Proline interacts with hydrophobic groups in the IgG molecule, thereby reducing protein-protein association and dimerization; in other words, it stabilizes IgG molecules as monomers.19 The images below show dimer formation in IgG solutions with proline and without proline.

Dimerization can occur without proline

Dimer fomation occurs without proline

In solution, IgG molecules (shown in blue) reversibly bind to each other (circled).19

Proline inhibits dimer formation and stabilizes IgG molecules

Proline reduces dimer formation

Proline may shield IgG molecules from binding together.19

Proline is rapidly cleared from circulation and does not accumulate after treatment.†20 Privigen is contraindicated in patients with hyperprolinemia.

†Clinical significance is unknown.

Designed for tolerability in a wide range of patients21

Privigen may be an option for patients with diabetes, latex allergy, and sensitivity to preservatives


Designed for stability, Privigen is also safe and effective

See how Privigen did in clinical studies

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