Proline interacts with hydrophobic groups in the IgG molecule, thereby reducing protein-protein association and dimerization; in other words, it stabilizes IgG molecules as monomers.17 The images below show dimer formation in IgG solutions with proline and without proline.
In solution, IgG molecules (shown in blue) reversibly bind to each other (circled), forming IgG dimers.17
Proline (shown in yellow) may shield the IgG molecules from one another and thus interfere with dimer formation.17
IVIg therapies designed with proline may be considered for patients with diabetes and certain allergies and intolerances.19
See how Privigen did in clinical studies